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職稱：副教授

學(xué)歷：博士研究生

電子郵件：qushuai@pku.edu.cn

研究方向：基因治療；脂質(zhì)納米顆粒（LNP）；超聲介導(dǎo)的藥物遞送

研究生招生專業(yè)：生物醫(yī)學(xué)工程（學(xué)碩）、生物技術(shù)與工程（專碩）

教育工作經(jīng)歷：

2024.08-至今：beat365在線體育官網(wǎng)，beat365在線體育官網(wǎng)，副教授

2018.09-2024.07：北京大學(xué)，生物醫(yī)學(xué)工程專業(yè)，博士研究生

2014.09-2018.07：哈爾濱工業(yè)大學(xué)，生物工程專業(yè)，本科

科研簡(jiǎn)介：

專注于開發(fā)高效、特異的體內(nèi)基因遞送策略。通過(guò)篩選優(yōu)化脂質(zhì)納米粒（LNP）及設(shè)計(jì)優(yōu)化mRNA序列，使其能夠聯(lián)合超聲靶向微泡空化實(shí)現(xiàn)靶向體內(nèi)特定組織器官乃至特定類群細(xì)胞遞送mRNA，同時(shí)屏蔽外源mRNA在非超聲輻照部位的表達(dá)，實(shí)現(xiàn)體內(nèi)定點(diǎn)的基因表達(dá)乃至基因編輯，用于治療動(dòng)脈粥樣硬化、癌癥等疾病。

其他：光動(dòng)力療法（PDT）

代表性論文：

[1] Qu, S^#., Liu, R^#., Zhang, N., Xu, Y., Yue, X., & Dai, Z. (2022). Non-viral nucleic acid therapeutics: Revolutionizing the landscape of atherosclerotic treatment. Nano Today, 45, 101514.

[2] Liu, R^#., Qu, S^#., Xu, Y., Jo, H., & Dai, Z. (2022). Spatial control of robust transgene expression in mouse artery endothelium under ultrasound guidance. Signal Transduction and Targeted Therapy, 7(1), 225.

[3] Qu, S., Liu, R., & Dai, Z. (2022). Imaging-guided gene delivery: seeing is delivering. Journal of Bio-X Research, 5(04), 143-144.

[4] Xin, Z., Qu, S., Qu, Y., Xu, Y., Liu, R., Sun, D., & Dai, Z. (2024). Emerging IL-12-based nanomedicine for cancer therapy. Nano Today, 57, 102331.

[5] Liu, R^#., Yang, H^#., Qu, S., Yang, P., Zhi, X., Xu, Y., Dai, Z., Qian, L (2023). Photodynamic eradication of intratumoral microbiota with bacteria-targeted micelles overcomes gemcitabine resistance of pancreatic cancer. Aggregate, 00, e423.

[6] Liu, R., Xu, Y., Qu, S., & Dai, Z. (2023). Major Strategies for Spatial Control of Ultrasound-Driven Gene Expression to Enhance Therapeutic Specificity. Critical Reviews? in Biomedical Engineering, 51(1).

[7] Xu, Y., Liu, R., Yang, H., Qu, S., Qian, L., & Dai, Z. (2022). Enhancing Photodynamic Therapy Efficacy Against Cancer Metastasis by Ultrasound-Mediated Oxygen Microbubble Destruction to Boost Tumor-Targeted Delivery of Oxygen and Renal-Clearable Photosensitizer Micelles. ACS Applied Materials & Interfaces.

[8] Liu, R., Xu, Y., Zhang, N., Qu, S., Zeng, W., Li, R., & Dai, Z. (2022). Nanotechnology for Enhancing Medical Imaging. In: Gu, N. (eds) Nanomedicine. Micro/Nano Technologies. Springer, Singapore.

[9] Liu, W., Han, F., Qu, S., Yao, Y., Zhao, J., Akhtar, M. L., ... & Li, Y. (2018). MARVELD1 depletion leads to dysfunction of motor and cognition via regulating glia-dependent neuronal migration during brain development. Cell death & disease, 9(10), 1-17.

[10] Li, K^#., Qu, S^#., Chen, X., Wu, Q., & Shi, M. (2017). Promising targets for cancer immunotherapy: TLRs, RLRs, and STING-mediated innate immune pathways. International journal of molecular sciences, 18(2), 404.

獲獎(jiǎng)情況：

北京大學(xué)優(yōu)秀畢業(yè)生，2024