以第一作者或通訊作者發(fā)表的主要論文： 1. Multienzymatic Cascade for Synthesis of Hydroxytyrosol via TwoStage Biocatalysis. Journal of Agricultural and Food Chemistry, 2024. 2. Single-cell enzymatic cascade synthesis of testolactone enabled by engineering of polycyclic ketone monooxygenase and multi-gene expression fine-tuning. International Journal of Biological Macromolecules, 2024. 3. Advances in Enzymatic Incorporation of Small Fluorine Modules. European Journal Organic Chemistry, 2024. 4. An artificial biocatalytic cascade for efficient synthesis of norepinephrine by combination of engineered L-threonine transaldolase with multi-enzyme expression fine-tuning. International Journal of Biological Macromolecules, 2024. 5. Development of whole cell biocatalytic system for asymmetric synthesis of esomeprazole with enhancing coenzyme biosynthesis pathway. Enzyme and Microbial Technology, 2024. 6. Efficiently manufacturing ectoine via metabolic engineering and protein engineering of L-2,4-diaminobutyrate transaminase. International Journal of Biological Macromolecules, 2024. 7. Immobilization of laccase on mesoporous metal organic frameworks for efcient cross coupling of ethyl ferulate. World Journal of Microbiology and Biotechnology, 2024. 8. Rational design of short‐chain dehydrogenase/reductase for enantio‐complementary synthesis of chiral 1,2‐diols by successive hydroxymethylation and reduction of aldehydes. Biotechnology and Bioengineering, 2024. 9. Rational design on loop regions for precisely regulating flexibility of catalytic center to mitigate overoxidation of prazole sulfides by Baeyer-Villiger monooxygenase. Bioorganic Chemistry, 2024. 10. Batch and continuous flow asymmetric synthesis of anabolic-androgenic steroids via a single-cell biocatalytic Δ1 -dehydrogenation and C17β-carbonyl reduction cascade. Green Chemistry, 2023. 11. A chemoenzymatic process for preparation of highly purified dehydroepiandrosterone in high space-time yield. Bioorganic Chemistry, 2023. 12. A chemoenzymatic strategy for the efficient synthesis of amphenicol antibiotic chloramphenicol mediated by an engineered L-threonine transaldolase with high activity and stereoselectivity, Catalysis Science & Technology, 2023. 13. Efficient synthesis of 2’-deoxyguanosine in one-pot cascade by employing an engineered purine nucleoside phosphorylase from Brevibacterium acetylicum. World Journal of Microbiology and Biotechnology, 2023. 14. Engineering of carbonyl reductase for asymmetric reduction of difficult-to-reduce ketone tetrahydrofuran-3-one. Molecular Catalysis, 2023. 15. Immobilization of laccase on magnetic nanoparticles for enhanced polymerization of phenols. Enzyme and Microbial Technology, 2023. 16. Improved Antimicrobial Activity of Bovine Lactoferrin Peptide (LFcinB) Based on Rational Design. The Protein Journal, 2023. 17. Multiplex metabolic pathway engineering of Monascus pilosus enhances lovastatin production. Applied Microbiology and Biotechnology, 2023. 18. Construction of an Efficient Non-natural Enzyme System for Preparation of Testosterone in High Space-Time Yield. ACS Sustainable Chemistry & Engineering, 2022. 19. Focused mutagenesis in non-catalytic cavity for improving catalytic efficiency of -ketosteroid -Δ1-dehydrogenase, Molecular Catalysis, 2022. 20. “Nonpolarity paving” in substrate tunnel of a Limnobacter sp. Phenylacetone monooxygenase for efficient single whole-cell synthesis of esomeprazole. Bioorganic Chemistry, 2022. 21. An Effective Chemo-Enzymatic method with An Evolved L-Threonine Aldolase for Preparing L-threo-4-Methylsulfonylphenylserine Ethyl Ester of High Optical Purity. Molecular Catalysis, 2022. 22. Engineered Cyclohexylamine Oxidase with Improved Activity and Stereoselectivity for Asymmetric Synthesis of a Bulky Dextromethorphan Precursor and Its Analogues. ChemCatChem, 2022. 23. Construction of efficient enzyme systems for preparing chiral ethyl 3-hydroxy- 3 -phenylpropionate. Enzyme and Microbial Technology, 2022. 24. Efficient biosynthesis of (2S, 3R)-4-methylsulfonylphenylserine by artificial self-assembly of enzyme complex combined with an intensified acetaldehyde elimination system. Bioorganic Chemistry, 2021. 25. Improving the Cβ Stereoselectivity of l-Threonine Aldolase for the Synthesis of l-threo-4-Methylsulfonylphenylserine by Modulating the Substrate-Binding Pocket To Control the Orientation of the Substrate Entrance. Chemistry—A European Journal, 2021. 26. Design of a PL18 alginate lyase with flexible loops and broader entrance to enhance the activity and thermostability. Enzyme and Microbial Technology, 2021. 27. Single-Point Mutation Near Active Center Increases Substrate Affinity of Alginate Lyase AlgL-CD. Applied Biochemistry and Biotechnology, 2021. 28. Multi-enzyme cascade for improving ?-hydroxy-a-amino acids production by engineering L- threonine transaldolase and combining acetaldehyde elimination system. Bioresource Technology, 2020. 29. Asymmetric Synthesis of a Key Dextromethorphan Intermediate and Its Analogs Enabled by a New Cyclohexylamine Oxidase: Enzyme Discovery, Reaction Development, and Mechanistic Insight. Journal of Organic Chemistry, 2020. 30. A L-threonine aldolase for asymmetric synthesis of β-hydroxy-α-amino acids. Chemical Engineering Science, 2020. 31. Expression and characterization of a chitinase from Serratia marcescens. Protein Expression and Puri?cation, 2020. 32. Rational Design of Dehydrogenase/Reductases Based on Comparative Structural Analysis of Prereaction-State and Free-State Simulations for E?cient Asymmetric Reduction of Bulky Aryl Ketones. ACS Catalysis, 2019. 33. Characteristics of L-threonine transaldolase for asymmetric synthesis of β-hydroxy-α-amino acids. Catalysis Science & Technology, 2019. 34. Truncation of κ?carrageenase for higher κ?carrageenan oligosaccharides yield with improved enzymatic characteristics. International Journal of Biological Macromolecules, 2019. 35. Mutagenesis on the surface of a β-agarase from Vibrio sp. ZC-1 increased its thermo-stability. Enzyme and Microbial Technology, 2019. 36. Inhibitory mechanism of Penicillin V on mushroom tyrosinase. Molecular Biology Reports, 2019. 37. Prediction of zinc-binding sites using multiple sequence profiles and machine learning methods. Molecular Omics, 2019. 38. Preparation of bioactive neoagaroligosaccharides through hydrolysis of Gracilaria lemaneiformis agar: A comparative study. Food Chemistry, 2018. 39. A Novel Multi-domain High Molecular, Salt-Stable Alkaline Xylanase from Alkalibacterium sp. SL3. Frontiers in Microbiology, 2017. 40. Inactivation kinetics and conformation change of Hypocrea orientalis b-glucosidase with guanidine hydrochloride. Journal of Bioscience and Bioengineering, 2017. 41. Degradation of tetracycline by immobilized laccase and the proposed transformation pathway. Journal of Hazardous Materials, 2017. 42. Immobilized Cerrena sp. Laccase preparation, thermal inactivation, and operational stability in malachite green decolorization. Scientific Reports, 2017. 43. Laccases Production, Expression Regulation, and Applications in Pharmaceutical Biodegradation. Frontiers in Microbiology, 2017. 44. A novel cold-adapted and highly salt-tolerant esterase from Alkalibacterium sp. SL3 from the sediment of a soda lake. Scientific Reports, 2016. 45. Cross-linked enzyme aggregates of Cerrena laccase: Preparation, enhanced NaCl tolerance and decolorization of Remazol Brilliant Blue Reactive. Journal of the Taiwan Institute of Chemical Engineers, 2016. 46. Destaining of Coomassie Brilliant Blue R-250-stained polyacrylamide gels with fungal laccase. Analytical Biochemistry, 2016. 47. Laccase Production and Differential Transcription of Laccase Genes in Cerrena sp.in Response to Metal Ions, Aromatic Compounds, and Nutrients. Frontiers in Microbiology, 2016. 48. Optimal parameters for laccase-mediated destaining of Coomassie Brilliant Blue R-250-stained polyacrylamide gels. Data in Brief, 2016. 49. A neural network learning approach for improving the prediction of residue depth based on sequencederived features. RSC Advances, 2016. 50. Laccase Gene Family in Cerrena sp. HYB07: Sequences, Heterologous Expression and Transcriptional Analysis. Molecules, 2016. 51. Highly efficient expression and characterization of a β-mannanase from Bacillus subtilis in Pichia pastoris. Biotechnology and Applied Biochemistry, 2016. 52. The disruption of two salt bridges of the cold-active xylanase XynGR40 results in an increase in activity, but a decrease in thermostability. Biochem Biophys Res Commun, 2016. 53. Laccase-Catalyzed Decolorization of Malachite Green: Performance Optimization and Degradation Mechanism. PLOS ONE, 2015. 54. Molecular characterization of a thermophilic and salt and alkaline-tolerant xylanase from Planococcus sp. SL4, a strain isolated from the sediment of a soda lake. Journal of Microbiology and Biotechnology（JMB）, 2015. 55. Highly efficient expression and characterization of a β-mannanase from Bacillus subtilis in Pichia pastoris, Biotechnology and Applied Biochemistry, 2015. 56. A novel laccase from basidiomycete Cerrena sp.: Cloning, eterologousexpression, and characterization. International Journal of Biological Macromolecules, 2015. 57. Purification and Characterization of a Novel Laccase from Cerrena sp. HYB07 with Dye Decolorizing Ability. PLOS ONE, 2014. 58. High Phylogenetic Diversity of Glycosyl Hydrolase Family 10 and 11 Xylanases in the Sediment of Lake Dabusu in China. PLOS ONE, 2014. 59. Antioxidant activities of kombucha prepared from three different substrates and changes in content of probiotics during storage. Food Science and Technology, 2014. |
