科研簡介： 主要研究領域為： （1）無細胞轉(zhuǎn)錄翻譯系統(tǒng) Cell-free transcription-translation systems； （2）基因回路與生物探測器 Genetic circuits and biosensors； （3）蛋白質(zhì)高通量表達和篩選 High-throughput screening of proteins/enzymes. Our group mainly focuses on prototyping and building novel biological circuits in both cell-free systems and cells, and using synthetic biology tools to advance the discovery of new enzymes. We are interested in utilizing cell-free systems to assist the research in synthetic biology by performing fast prototyping on biological parts and modules, with the goals of building novel biological circuits and metabolic pathways to tackle various problems. 歡迎對合成生物學感興趣的碩士生、本科生加入課題組！ |
代表性論著： 1. Guo, S., M. Wang, W. Xu, et al., Rapid screening of glycosyltransferases in plants using a linear DNA expression template based cell-free transcription-translation system. Phytochemistry, 2022. 193: p. 113007. 2. Wei, Z., X. Shi, R. Lian, et al., Exclusive Production of Gentamicin C1a from Micromonospora purpurea by Metabolic Engineering. Antibiotics (Basel), 2019. 8(4). 3. Guo, S. and R.M. Murray, Construction of Incoherent Feedforward Loop Circuits in a Cell-Free System and in Cells. ACS Synth Biol, 2019. 8(3): p. 606-610. 在研項目： 1. 國家自然科學基金青年科學基金項目：利用無細胞轉(zhuǎn)錄翻譯系統(tǒng)和生物回路實現(xiàn)植物糖基轉(zhuǎn)移酶的高通量研究（2020年-2023年） 2. 福建省科學技術廳自然科學基金項目：利用無細胞轉(zhuǎn)錄翻譯系統(tǒng)快速篩選植物糖基轉(zhuǎn)移酶的研究（2020年-2023年） |
