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beat365在線體育官網(wǎng)

College of Biological Science and Engineering

張曉龍*

發(fā)布日期:2013-06-27 發(fā)布者:

姓名:張曉龍

性別:

職稱副研究員/碩士生導(dǎo)師

學(xué)歷:博士

電子郵件: xiaolongdo@gmail.com

主要研究方向:納米生物醫(yī)學(xué),腫瘤分子影像,納米生物傳感

教育工作經(jīng)歷:

1.2005/9–2009/7,beat365在線體育官網(wǎng),化學(xué),學(xué)士

2.2009/9–2015/7,beat365在線體育官網(wǎng),分析化學(xué),博士

3.2015/7 至今,福建醫(yī)科大學(xué)孟超肝膽醫(yī)院,助理研究員,副研究員

4.2018/1 至今,beat365在線體育官網(wǎng)孟超醫(yī)學(xué)與交叉科學(xué)中心,副研究員

教學(xué)簡(jiǎn)介:


科研簡(jiǎn)介:主要從事腫瘤診斷分子影像探針和納米藥物的開發(fā)及應(yīng)用,實(shí)現(xiàn)腫瘤的光學(xué)成像、光動(dòng)力、光熱或化學(xué)治療等基礎(chǔ)研究工作。已在Acta Biomaterialia、Molecular Therarpy、Anal. Chem.、Chem. Commun.ACS Appl. Mater. Interfaces、TheranosticsBiosens. Bioelectron.、 Nanoscale、 Sensors & Actuators: B. Chemical、Microchimica Acta、TalantaAnalytical and Bioanalytical Chemistry等等國(guó)際刊物發(fā)表SCI論文20余篇。主持國(guó)家自然科學(xué)基金項(xiàng)目1項(xiàng),省部級(jí)項(xiàng)目3項(xiàng)。2021年入選福建省高層次人才(C類)。

社會(huì)兼職:Theranostics》、《Acta Biomaterialia》、《Materials Today Bio》、《Materials & Design》、《Frontiers in Chemistry》、《Talanta》、《Arabian Journal of Chemistry》、《Analytical Biochemistry》、《International Journal of Nanomedicine等雜志審稿人。

科研項(xiàng)目:

1. 福建省自然科學(xué)基金面上項(xiàng)目,2021J011281,仿生納米材料協(xié)同化學(xué)動(dòng)力和光動(dòng)力治療乏氧腫瘤,2021/11-2024/11,7萬元,在研,主持

2. 福建省衛(wèi)健委醫(yī)學(xué)創(chuàng)新課題,2021CXA043,光敏劑和核酸共遞送納米體系用于乏氧腫瘤的基因-光動(dòng)力治療協(xié)同增效研究,2022/1-2024/12,15萬元,在研,主持

3. 國(guó)家自然科學(xué)基金青年項(xiàng)目,21605021,核酸功能化聚吡咯納米體系在腫瘤細(xì)胞靶向成像與治療中的研究,2017/01-2019/12,20萬,結(jié)題,主持

4. 福建省自然科學(xué)基金-青年科技人才創(chuàng)新項(xiàng)目,2016J05206,核酸功能化熒光納米探針在細(xì)胞內(nèi)谷胱甘肽實(shí)時(shí)成像的研究,2016/4-2019/4,4萬元,結(jié)題,主持

5. 福建省科技創(chuàng)新聯(lián)合資金項(xiàng)目,2016Y9060,功能納米材料在腫瘤細(xì)胞靶向治療及細(xì)胞凋亡成像中的應(yīng)用研究,2016/9-2019/910萬元,結(jié)題,主持

6. 福建省衛(wèi)生計(jì)生科研人才培養(yǎng)項(xiàng)目-中青年骨干人才培養(yǎng)項(xiàng)目, 2018-ZQN-75,腫瘤微環(huán)境響應(yīng)納米藥物用于增強(qiáng)光動(dòng)力治療的研究,2018/5-2021/410萬,結(jié)題,主持


已發(fā)表論文:(*為通訊作者,#為共同一作)

(1) Lei Ding#, Xiaolong Zhang#, Peiwen Yu, Fang Peng, Yupeng Sun,Yanni Wu, Zijin Luo, Hongsheng Li, Yongyi Zeng, Ming Wu*, Xiaolong Liu*, Genetically engineered nanovesicles mobilize synergistic antitumor immunity by ADAR1 silence and PDL1 blockade, Molecular Therapy, 2023, 10.1016/j.ymthe.2023.04.011.

(2) Yanni Wu#, Lei Ding#, Cheng Zheng, Hongsheng Li, Ming Wu, Yupeng Sun, Xiaolong Liu, Xiaolong Zhang*, Yongyi Zeng*, Targeted co-delivery of a photosensitizer and an antisense oligonucleotide based on an activatable hyaluronic acid nanosystem with endogenous oxygen generation for enhanced photodynamic therapy of hypoxic tumors. Acta Biomaterialia, 2022,153, 419-430.

(3) Xiaolong Zhang, Cheng Zheng, Lei Ding, Yanni Wu, Haipo Xu, Yupeng Sun, Yongyi Zeng, Xiaolong Liu*, Jingfeng Liu*, CRISPR-Cas12a coupled with terminal deoxynucleotidyl transferase mediated isothermal amplification for sensitive detection of polynucleotide kinase activity, Sensors & Actuators: B. Chemical, 2021, 330, 129317.

(4) Xiaolong Zhang, Ming Wu, Jiong Li, Shanyou Lan, Yongyi Zeng, Xiaolong Liu,* Jingfeng Liu*, Light-enhanced hypoxia-response of conjugated polymer nanocarrier for successive synergistic photodynamic and chemo-therapy, ACS Appl. Mater. Interfaces, 2018, 10 (26), 21909–21919.

(5) Lei Ding#, Xiao Lin#, Ziguo Lin, Yanni Wu, Xiaolong Liu, Jingfeng Liu, Ming Wu, Xiaolong Zhang*, Yongyi Zeng*, Cancer cell-targeted photosensitizer and therapeutic protein co-delivery nanoplatform based on a metal-organic framework for enhanced synergistic photodynamic and protein therapy. ACS Applied Materials & Interfaces, 2020, 12(33): 36906-36916.

(6) Lei Ding#, Yanni Wu#, Ming Wu, Qingfu Zhao, Hongsheng Li, Jingfeng Liu, Xiaolong Liu, Xiaolong Zhang*, Yongyi Zeng*, Engineered red blood cell biomimetic nanovesicle with oxygen self-supply for near-infrared-II fluorescence-guided synergetic chemo-photodynamic therapy against hypoxic tumors. ACS Applied Materials & Interfaces, 2021, 13(44): 52435-52449.

(7) Xiaolong Zhang, Xionghong Tan, Da Zhang, Naishun Liao, Youshi Zheng, Aixian Zheng, Yongyi Zeng, Xiaolong Liu *, Jingfeng Liu*, A cancer cell specific targeting nanocomplex for combination of mRNA-responsive photodynamic and chemo-therapy. Chemical Communications, 2017,53, 9979-9982.

(8) Xiaolong Zhang, Naishun Liao, Geng Chen, Aixian Zheng, Yongyi Zeng, Xiaolong Liu*, Jingfeng Liu*, A fluorescent turn on nanoprobe for simultaneous visualization of dual-targets involved in cell apoptosis and drug screening in living cells. Nanoscale, 2017, 9(30): 10861-10868.  

(9) Xiaolong Zhang#, Yongyi Zeng#, Aixian Zheng, Zhixiong Cai, Aimin Huang, Jinhua Zeng, Xiaolong Liu*, Jingfeng Liu*, A fluorescence based immunoassay for galectin-4 using gold nanoclusters and a composite consisting of glucose oxidase and a metal-organic framework, Microchim Acta, 2017, 184,1933–1940.

(10) Jing Wang#, Cheng Zheng#, Xionghong Tan, Aixian Zheng, Yongyi Zeng, Zhenxi Zhang, Xiaolong Zhang,* Xiaolong Liu,* Sensitive fluorometric determination of glutathione using fluorescent polymer dots and the dopamine-melanin nanosystem, Microchimica Acta, 2019, 186(8):568.

(11) Cheng Zheng, Lei Ding, Yanni Wu, Xionghong Tan, Yongyi Zeng, Xiaolong Zhang*, Xiaolong Liu, Jingfeng Liu*, A near-infrared turn-on fluorescence probe for glutathione detection based on nanocomposites of semiconducting polymer dots and MnO2 nanosheets, Analytical and Bioanalytical Chemistry, 2020, 412(29): 8167-8176.

授權(quán)發(fā)明專利:

(1) 張曉龍劉景豐劉小龍曾永毅吳名一種乏氧響應(yīng)聚合物納米粒及其應(yīng)用, 中國(guó),ZL201810532353.4

(2) 張曉龍,曾永毅,劉小龍,丁磊,一種同時(shí)包載光敏劑和蛋白質(zhì)的腫瘤靶向納米藥物及其應(yīng)用,中國(guó),ZL202010653123.0

(3) 楊黃浩,宋良,田中群,張曉龍,一種利用拉曼增強(qiáng)光譜檢測(cè)食品中合成色素的方法,中國(guó),CN201310295760.5

(4) 劉景豐,劉小龍,張曉龍,廖乃順,鄭愛仙曾永毅,一種細(xì)胞凋亡雙色檢測(cè)和成像探針及其應(yīng)用,中國(guó)CN201710432782.X。

(5) 楊黃浩,張曉龍,鄭琤,梁虹,一種金納米星及其制備方法和應(yīng)用,中國(guó),CN201510114250.2

(6) 劉景豐,曾永毅,劉小龍,張曉龍,鄭愛仙,廖乃順,一種檢測(cè)galectin?4的熒光酶聯(lián)免疫分析方法,中國(guó),CN 201610539941.1


獲獎(jiǎng)情況

(1) 肝癌微創(chuàng)與診療一體化技術(shù)的研究及應(yīng)用,福建省科學(xué)技術(shù)廳,科技進(jìn)步一等獎(jiǎng),2022(劉景豐、劉小龍、曾永毅、張達(dá)、王培園、李陽(yáng)、吳名、張翔、趙必星、張曉龍

(2) 光增強(qiáng)乏氧響應(yīng)共軛聚合物納米載體用于級(jí)聯(lián)協(xié)同光動(dòng)力和化學(xué)治療, 福州市科學(xué)技術(shù)協(xié)會(huì)、中共福州市委組織部、福州市人力資源和社會(huì)保障局,2020,福州市自然科學(xué)優(yōu)秀學(xué)術(shù)論文二等獎(jiǎng)

其他

研究生招生專業(yè):生物醫(yī)學(xué)工程(學(xué)碩);生物工程(學(xué)碩);生物技術(shù)與工程(生物與醫(yī)藥專碩)。歡迎有志青年報(bào)考課題組研究生!

課題組網(wǎng)站:https://www.x-mol.com/groups/Liu_Xiaolong